Fire in San Andreas
Practical fire and explosion effects are not unheard of, but it is often much preferable to use SFX for these scenes. That was what happened in this shot.
Fire in San Andreas
As you can see here, the main rubble was present on the set for realism. However, everything that might be dangerous had been added during post-production.
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Characters in Alice in Wonderland
There is no way to show fully fleshed out fantastical characters and creatures without using CGI! As you can see here, Tweedledee, Tweedledum, and the Knave of Hearts came to life this way.
Characters in Alice in Wonderland
When it came to the actual filming, the actors had to don large green screen suits. The editors only added in the details later on.